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Alpha-mangostin에 의한 Arginine-132이 Histidine으로 돌연변이가 일어난 Isocitrate Dehydrogenase-1 (IDH1-R132H) 단백질의 활성 억제 효과PHAMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING GLIOMA COMPRISING ALPHA-MANGOSTIN AS A EFFECTIVE COMPONENT
- Alternative Title
- PHAMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING GLIOMA COMPRISING ALPHA-MANGOSTIN AS A EFFECTIVE COMPONENT
- Abstract
- 본 연구진은 천연물에서 IDH1-R132H 단백질의 저해제 검색을 통하여 alpha-mangostin이 IDH1 단백질의 활성은 영향을 주지 않고 IDH1-R132H 단백질의 효능만을 억제하는 새로운 저해제 임을 밝혀 내었다.
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Collections - College of Pharmacy > Department of Pharmacy > 4. Patents
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Related Researcher
- Keum, Young Sam
- College of Pharmacy (Department of Pharmacy)