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Calcium(ii)-catalyzed [2+3] annulation of enynones: a sustainable approach to 9H-pyrrolo[1,2-a]indole frameworksopen access
- Authors
- Kale, Ashok; Rivonker, Shubham C.; Kim, Jong-hyuk; Hwang, Jong Yeon; Choi, Yongseok; Lee, Kyeong
- Issue Date
- Jul-2025
- Publisher
- Royal Society of Chemistry
- Keywords
- Alcohol; Calcium; Calcium Compounds; Polycyclic Aromatic Hydrocarbons; Regioselectivity; Synthesis (chemical); Annulation Reactions; Atom Economic; Functionals; Gram Scale; Regio-selective; Substitution Patterns; Synthesised; Synthetic Transformations; Synthetic Utility; Tryptamines; Catalysis; 9h Pyrrolo[1,2 A]indole; Alcohol; Calcium; Chemical Compound; Enynone; Ketone; Unclassified Drug; Tryptamine Derivative; Antineoplastic Activity; Article; Catalysis; Chemical Analysis; Drug Toxicity; Economic Aspect; Nonhuman; Nuclear Magnetic Resonance; Synthetic Biology; X Ray Crystallography; Annulation Reaction; Article; Controlled Study; Drug Analysis; Drug Development
- Citation
- Chemical Communications, v.61, no.62, pp 11689 - 11692
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- Chemical Communications
- Volume
- 61
- Number
- 62
- Start Page
- 11689
- End Page
- 11692
- ISSN
- 1359-7345
1364-548X
- Abstract
- A Ca(ii)-catalyzed, atom-economic, and regioselective [2+3] annulation reaction has been developed to synthesize 9H-pyrrolo[1,2-a]indoles by using easily accessible tryptamines and enynones. This protocol exhibits broad functional group tolerance; thus, 9H-pyrrolo[1,2-a]indole frameworks with diverse substitution patterns can be synthesized. The synthetic utility of this method is further demonstrated through its effectiveness in gram-scale preparations and versatile synthetic transformations.
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Related Researcher
- Lee, Kyeong
- College of Pharmacy (Department of Pharmacy)