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Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes
- Authors
- Lee, Kyeong; Ban, Hyun Seung; Naik, Ravi; Hong, Ye Seul; Son, Seohyun; Kim, Bo-Kyung; Xia, Yan; Song, Kyung Bin; Lee, Hong-Sub; Won, Misun
- Issue Date
- 23-Sep-2013
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- click chemistry; fluorescent probes; HIF inhibitors; malate dehydrogenase2; photoaffinity labeling
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.52, no.39, pp 10286 - 10289
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Volume
- 52
- Number
- 39
- Start Page
- 10286
- End Page
- 10289
- ISSN
- 1433-7851
1521-3773
- Abstract
- Tracking the target: To identify a protein that binds directly to the HIF-1α inhibitor LW6, a series of new chemical probes were synthesized with a clickable tag and/or a photoactivatable moiety. LW6 was found to be localized to the mitochondria (see picture) and MDH2 was identified as a target protein of LW6. These results indicate that the HIF-1α inhibitory activity of LW6 is a consequence of MDH2 suppression. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Related Researcher
- Lee, Kyeong
- College of Pharmacy (Department of Pharmacy)