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Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lee, Kyeong | - |
| dc.contributor.author | Ban, Hyun Seung | - |
| dc.contributor.author | Naik, Ravi | - |
| dc.contributor.author | Hong, Ye Seul | - |
| dc.contributor.author | Son, Seohyun | - |
| dc.contributor.author | Kim, Bo-Kyung | - |
| dc.contributor.author | Xia, Yan | - |
| dc.contributor.author | Song, Kyung Bin | - |
| dc.contributor.author | Lee, Hong-Sub | - |
| dc.contributor.author | Won, Misun | - |
| dc.date.accessioned | 2024-09-26T13:01:23Z | - |
| dc.date.available | 2024-09-26T13:01:23Z | - |
| dc.date.issued | 2013-09-23 | - |
| dc.identifier.issn | 1433-7851 | - |
| dc.identifier.issn | 1521-3773 | - |
| dc.identifier.uri | https://scholarworks.dongguk.edu/handle/sw.dongguk/25022 | - |
| dc.description.abstract | Tracking the target: To identify a protein that binds directly to the HIF-1α inhibitor LW6, a series of new chemical probes were synthesized with a clickable tag and/or a photoactivatable moiety. LW6 was found to be localized to the mitochondria (see picture) and MDH2 was identified as a target protein of LW6. These results indicate that the HIF-1α inhibitory activity of LW6 is a consequence of MDH2 suppression. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. | - |
| dc.format.extent | 4 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | WILEY-V C H VERLAG GMBH | - |
| dc.title | Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes | - |
| dc.type | Article | - |
| dc.publisher.location | 독일 | - |
| dc.identifier.doi | 10.1002/anie.201304987 | - |
| dc.identifier.scopusid | 2-s2.0-84884824876 | - |
| dc.identifier.wosid | 000329141800024 | - |
| dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.52, no.39, pp 10286 - 10289 | - |
| dc.citation.title | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
| dc.citation.volume | 52 | - |
| dc.citation.number | 39 | - |
| dc.citation.startPage | 10286 | - |
| dc.citation.endPage | 10289 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | INDUCIBLE FACTOR-I | - |
| dc.subject.keywordAuthor | click chemistry | - |
| dc.subject.keywordAuthor | fluorescent probes | - |
| dc.subject.keywordAuthor | HIF inhibitors | - |
| dc.subject.keywordAuthor | malate dehydrogenase2 | - |
| dc.subject.keywordAuthor | photoaffinity labeling | - |
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Related Researcher
- Lee, Kyeong
- College of Pharmacy (Department of Pharmacy)