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Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity
- Authors
- Yoo, Hunseung; Chae, Hee-Sung; Kim, Young-Mi; Kang, Minseok; Ryu, Keun Ho; Ahn, Hee Chul; Yoon, Kee Dong; Chin, Young-Won; Kim, Jinwoong
- Issue Date
- 15-Dec-2014
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Sophora tonkinensis; Flavonoid; Arylbenzofruran; Interleukin-6; Anti-allergy
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.24, no.24, pp 5644 - 5647
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 24
- Number
- 24
- Start Page
- 5644
- End Page
- 5647
- ISSN
- 0960-894X
1464-3405
- Abstract
- Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
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Related Researcher
- Ahn, Hee Chul
- College of Pharmacy (Department of Pharmacy)