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Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris
- Authors
- Lee, Shinae; Son, Min-Gyung; Kim, Young-Mi; An, Chae-Yeong; Kim, Hyun Ji; Nhoek, Piseth; Pel, Pisey; Won, Hongic; Lee, Yoonkyung; Yun, Narae; Paik, Jin-Hyub; Bazarragchaa, Badamtsetseg; Kim, Hyun Woo; Choi, Young Hee; Oh, Won Keun; Lee, Chang Hoon; Chin, Young-Won
- Issue Date
- Jun-2024
- Publisher
- Elsevier BV
- Keywords
- Asteraceae; Dihydrostilbenes; Flavonoids; Jacobaea vulgaris; LDLR; PCSK9
- Citation
- Phytochemistry, v.222, pp 1 - 11
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- Phytochemistry
- Volume
- 222
- Start Page
- 1
- End Page
- 11
- ISSN
- 0031-9422
1873-3700
- Abstract
- The isolation of previously undescribed 12 compounds from the MeOH extract of Jacobaea vulgaris whole plants is disclosed, comprising 11 dihydrostilbenes (1–11) and one flavanone (12), and eight known compounds (six flavonoids, one dihydrostilbene, and one caffeoylquinic acid). Structural elucidation employed spectroscopic methods, including 1D and 2D NMR spectroscopy, HRESIMS, and ECD calculations. Evaluation of the compounds’ effects on PCSK9 and LDLR mRNA expression revealed that compounds 1 and 3 downregulated PCSK9 mRNA while increasing LDLR mRNA expression, suggesting potential cholesterol-lowering properties. © 2024 Elsevier Ltd
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Related Researcher
- Lee, Chang Hoon
- College of Pharmacy (Department of Pharmacy)