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Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris

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dc.contributor.authorLee, Shinae-
dc.contributor.authorSon, Min-Gyung-
dc.contributor.authorKim, Young-Mi-
dc.contributor.authorAn, Chae-Yeong-
dc.contributor.authorKim, Hyun Ji-
dc.contributor.authorNhoek, Piseth-
dc.contributor.authorPel, Pisey-
dc.contributor.authorWon, Hongic-
dc.contributor.authorLee, Yoonkyung-
dc.contributor.authorYun, Narae-
dc.contributor.authorPaik, Jin-Hyub-
dc.contributor.authorBazarragchaa, Badamtsetseg-
dc.contributor.authorKim, Hyun Woo-
dc.contributor.authorChoi, Young Hee-
dc.contributor.authorOh, Won Keun-
dc.contributor.authorLee, Chang Hoon-
dc.contributor.authorChin, Young-Won-
dc.date.accessioned2024-08-08T12:01:47Z-
dc.date.available2024-08-08T12:01:47Z-
dc.date.issued2024-06-
dc.identifier.issn0031-9422-
dc.identifier.issn1873-3700-
dc.identifier.urihttps://scholarworks.dongguk.edu/handle/sw.dongguk/21995-
dc.description.abstractThe isolation of previously undescribed 12 compounds from the MeOH extract of Jacobaea vulgaris whole plants is disclosed, comprising 11 dihydrostilbenes (1–11) and one flavanone (12), and eight known compounds (six flavonoids, one dihydrostilbene, and one caffeoylquinic acid). Structural elucidation employed spectroscopic methods, including 1D and 2D NMR spectroscopy, HRESIMS, and ECD calculations. Evaluation of the compounds’ effects on PCSK9 and LDLR mRNA expression revealed that compounds 1 and 3 downregulated PCSK9 mRNA while increasing LDLR mRNA expression, suggesting potential cholesterol-lowering properties. © 2024 Elsevier Ltd-
dc.format.extent11-
dc.language영어-
dc.language.isoENG-
dc.publisherElsevier BV-
dc.titleDihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris-
dc.typeArticle-
dc.publisher.location네델란드-
dc.identifier.doi10.1016/j.phytochem.2024.114107-
dc.identifier.scopusid2-s2.0-85191345652-
dc.identifier.wosid001236354500001-
dc.identifier.bibliographicCitationPhytochemistry, v.222, pp 1 - 11-
dc.citation.titlePhytochemistry-
dc.citation.volume222-
dc.citation.startPage1-
dc.citation.endPage11-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.subject.keywordPlusRAGWORT SENECIO-JACOBAEA-
dc.subject.keywordPlusPYRROLIZIDINE ALKALOIDS-
dc.subject.keywordPlusLDL RECEPTOR-
dc.subject.keywordPlusPCSK9 INHIBITORS-
dc.subject.keywordPlusAERIAL PARTS-
dc.subject.keywordPlus8-PRENYLNARINGENIN-
dc.subject.keywordPlusDIVERSITY-
dc.subject.keywordPlusIDOL-
dc.subject.keywordAuthorAsteraceae-
dc.subject.keywordAuthorDihydrostilbenes-
dc.subject.keywordAuthorFlavonoids-
dc.subject.keywordAuthorJacobaea vulgaris-
dc.subject.keywordAuthorLDLR-
dc.subject.keywordAuthorPCSK9-
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