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Two new lathyrane-type diterpenoid glycosides with IL-6 production inhibitory activity from the roots of Euphorbia kansui
- Issue Date
- 15-Apr-2018
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Euphorbia kansui; Kansuingol A; Kansuingol B; Anti-inflammatory; IL-6; TNF-alpha; Diterpenoid
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.28, no.7, pp 1207 - 1210
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 28
- Number
- 7
- Start Page
- 1207
- End Page
- 1210
- ISSN
- 0960-894X
1464-3405
- Abstract
- As part of our ongoing search for anti-inflammatory compounds from higher plants, we isolated and elucidated two new diterpenoid glycosides, kansuingol A (1) and kansuingol B (2), from the roots of Euphorbia kansui. These structures were elucidated by extensive spectroscopic methods such as NMR and MS. Compounds were assessed for their IL-6 production inhibitory activity in PMA + A23187-stimulated HMC-1 cells. As a result, compounds 1 and 2 exerted inhibitory activities in the production of IL-6 with IC50 values of 2.96, and 1.94 mu M, respectively. Further, kansuingol A (1) decreased mRNA expressions of TNF-alpha and IL-6. (C) 2018 Elsevier Ltd. All rights reserved.
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Related Researcher
- Choi, Young Hee
- College of Pharmacy (Department of Pharmacy)