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Riboflavin-UVA collagen cross-linking for the treatment of acanthamoeba keratitisopen access
- Authors
- Park, C.Y.; Chuck, R.S.
- Issue Date
- 1-Feb-2019
- Publisher
- AME Publishing Company
- Keywords
- Acanthamoeba; Collagen; Cross-linking; Keratitis; Riboflavin; Ultraviolet A (UVA)
- Citation
- Annals of Eye Science, v.4, no.2
- Indexed
- SCOPUS
- Journal Title
- Annals of Eye Science
- Volume
- 4
- Number
- 2
- ISSN
- 2520-4122
2520-4122
- Abstract
- In this review, recent studies regarding riboflavin-ultraviolet A (UVA) collagen cross-linking for the treatment of acanthamoeba keratitis (AK) were reviewed. English written studies about acanthamoeba, keratitis, riboflavin and collagen cross-linking were retrieved from PubMed search engine (www.ncbi.nlm.nih.gov/pubmed). Although there were significant numbers of cases reporting the effectiveness of riboflavin-UVA collagen cross-linking in AK, experimental studies (in vivo and in vitro) failed to verify amoebicidal or cysticidal effect of riboflavin-UVA collagen cross-linking. In conclusion, the efficacy of riboflavin-UVA collagen cross-linking for the treatment of AK is still debatable. It is necessary to conduct a prospective case-control study for clear guidance for clinicians. © 2019 AME Publishing Company. All rights reserved.
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Collections - Graduate School > Department of Medicine > 1. Journal Articles
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