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Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironmentopen access
- Authors
- Park, Mi Kyung; Lee, Chang Hoon
- Issue Date
- Nov-2019
- Publisher
- MDPI
- Keywords
- inflammatory; lysosphingolipids; neurological; sphingosylphosphorylcholine; tumor microenvironment
- Citation
- CANCERS, v.11, no.11
- Indexed
- SCIE
SCOPUS
- Journal Title
- CANCERS
- Volume
- 11
- Number
- 11
- ISSN
- 2072-6694
2072-6694
- Abstract
- Sphingosylphosphorylcholine (SPC) is a unique type of lysosphingolipid found in some diseases, and has been studied in cardiovascular, neurological, and inflammatory phenomena. In particular, SPC's studies on cancer have been conducted mainly in terms of effects on cancer cells, and relatively little consideration has been given to aspects of tumor microenvironment. This review summarizes the effects of SPC on cancer and tumor microenvironment, and presents the results and prospects of modulators that regulate the various actions of SPC.
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Related Researcher
- Lee, Chang Hoon
- College of Pharmacy (Department of Pharmacy)