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[우선권]신규 쿠드라플라본 J 유도체 (가칭)Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/HO-1 signaling
- Alternative Title
- Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/HO-1 signaling
- Abstract
- 1. Novel cudraisoflavone J analogs were designed and synthesized. 2. Compounds 13m and 24 extensively inhibited 6-OHDA- and rotenone-induced cell death. 3, 13m and 24 increased expression levels of HO-1 and Nrf2. 4. Nrf2/HO-1 pathway is mediated by phosphorylated ERK1/2, JNK, and Akt in PC12 cells. 5. 13m and 24 may be promising therapeutic candidates to prevent and/or treat PD.
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Collections - College of Pharmacy > Department of Pharmacy > 4. Patents
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Related Researcher
- Lee, Kyeong
- College of Pharmacy (Department of Pharmacy)