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Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples
- Authors
- Luong, Huy X.; Kim, Young-Woo
- Issue Date
- 16-Oct-2020
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.22, no.20, pp 7986 - 7990
- Pages
- 5
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC LETTERS
- Volume
- 22
- Number
- 20
- Start Page
- 7986
- End Page
- 7990
- ISSN
- 1523-7060
1523-7052
- Abstract
- Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some relationships between structural features and PPII stability in this model. This new macrocyclic stapling strategy can serve as a useful chemical tool to manipulate the PPII structure for various applications.
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Related Researcher
- Kim, Young Woo
- College of Pharmacy (Department of Pharmacy)