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Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Luong, Huy X. | - |
| dc.contributor.author | Kim, Young-Woo | - |
| dc.date.accessioned | 2023-04-27T21:40:33Z | - |
| dc.date.available | 2023-04-27T21:40:33Z | - |
| dc.date.issued | 2020-10-16 | - |
| dc.identifier.issn | 1523-7060 | - |
| dc.identifier.issn | 1523-7052 | - |
| dc.identifier.uri | https://scholarworks.dongguk.edu/handle/sw.dongguk/6012 | - |
| dc.description.abstract | Polyproline II helix (PPII) is one of the secondary structures in proteins that play an important role in various biological processes. In this study, we have developed a new macrocyclization strategy that efficiently reinforces a model tetrapeptide into a PPII structure. We also elucidated some relationships between structural features and PPII stability in this model. This new macrocyclic stapling strategy can serve as a useful chemical tool to manipulate the PPII structure for various applications. | - |
| dc.format.extent | 5 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | AMER CHEMICAL SOC | - |
| dc.title | Stabilization of Single Turn Polyproline II Helices via Macrocyclic Hydrocarbon Staples | - |
| dc.type | Article | - |
| dc.publisher.location | 미국 | - |
| dc.identifier.doi | 10.1021/acs.orglett.0c02914 | - |
| dc.identifier.scopusid | 2-s2.0-85093539476 | - |
| dc.identifier.wosid | 000607469900039 | - |
| dc.identifier.bibliographicCitation | ORGANIC LETTERS, v.22, no.20, pp 7986 - 7990 | - |
| dc.citation.title | ORGANIC LETTERS | - |
| dc.citation.volume | 22 | - |
| dc.citation.number | 20 | - |
| dc.citation.startPage | 7986 | - |
| dc.citation.endPage | 7990 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | PEPTIDES | - |
| dc.subject.keywordPlus | PROTEINS | - |
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Related Researcher
- Kim, Young Woo
- College of Pharmacy (Department of Pharmacy)