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Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironmentsopen access
- Authors
- Ha, Nguyen Thi; Lee, Chang Hoon
- Issue Date
- Nov-2020
- Publisher
- MDPI
- Keywords
- farnesyl-diphosphate farnesyltransferase 1; prognostic marker; lipid rafts; cholesterol synthesis; tumour progression
- Citation
- CELLS, v.9, no.11, pp 1 - 33
- Pages
- 33
- Indexed
- SCIE
SCOPUS
- Journal Title
- CELLS
- Volume
- 9
- Number
- 11
- Start Page
- 1
- End Page
- 33
- ISSN
- 2073-4409
2073-4409
- Abstract
- Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.
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Related Researcher
- Lee, Chang Hoon
- College of Pharmacy (Department of Pharmacy)