Association between transient tachypnea of newborn and bronchiolitis development

Abstract

Purpose: Transient tachypnea of newborn (TTN) is characterized by inadequate absorption of fetal lung fluid. While typically benign and self-limiting, TTN may be associated with an increased risk of wheezing syndromes. This study aimed to investigate the association between TTN and the development of bronchiolitis within the first 2 years of life. Methods: A retrospective cohort study included 184 newborns with TTN and 213 healthy controls, all born between January 1, 2006, and December 31, 2019. Medical records were analyzed for demographics, bronchiolitis incidence, and viral etiology. Results: The incidence of bronchiolitis was significantly higher in the TTN group (29.3%) than in the healthy controls (14.1%) (P<0.01). TTN was identified as an independent risk factor for bronchiolitis (odds ratio, 2.44; 95% confidence interval, 1.45–4.11). Conclusion: TTN may be a potential risk factor for bronchiolitis development. Further research is needed to clarify the possible association and underlying mechanisms linking TTN and bronchiolitis.