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Therapeutic Effects of Specialized Pro-Resolving Lipids Mediators on Cardiac Fibrosis via NRF2 Activationopen access
- Authors
- Kang, Gyeoung Jin; Kim, Eun Ji; Lee, Chang Hoon
- Issue Date
- Dec-2020
- Publisher
- MDPI
- Keywords
- cardiac fibrosis; NRF2; lipoxins; resolvins; maresins; neuroprotectins
- Citation
- ANTIOXIDANTS, v.9, no.12, pp 1 - 27
- Pages
- 27
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANTIOXIDANTS
- Volume
- 9
- Number
- 12
- Start Page
- 1
- End Page
- 27
- ISSN
- 2076-3921
2076-3921
- Abstract
- Heart disease is the number one mortality disease in the world. In particular, cardiac fibrosis is considered as a major factor causing myocardial infarction and heart failure. In particular, oxidative stress is a major cause of heart fibrosis. In order to control such oxidative stress, the importance of nuclear factor erythropoietin 2 related factor 2 (NRF2) has recently been highlighted. In this review, we will discuss the activation of NRF2 by docosahexanoic acid (DHA), eicosapentaenoic acid (EPA), and the specialized pro-resolving lipid mediators (SPMs) derived from polyunsaturated lipids, including DHA and EPA. Additionally, we will discuss their effects on cardiac fibrosis via NRF2 activation.
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Related Researcher
- Lee, Chang Hoon
- College of Pharmacy (Department of Pharmacy)