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Association of Chronic Kidney Disease With Increased Glucose Uptake-Associated Metabolic Activity of Visceral Adipose and Subcutaneous Adipose Tissue in Patients With Gout
- Authors
- Kaneshita, Shunya; Fukui, Sho; Niku, Soheil; Lee, Kwanghoon; Belezzuoli, Ernest; Terkeltaub, Robert; Guma, Monica
- Issue Date
- Aug-2025
- Publisher
- WILEY
- Keywords
- Allopurinol; Febuxostat; Metformin; Fluorodeoxyglucose F 18; Glucose; Fluorodeoxyglucose F18; Glucose; Radiopharmaceuticals; Allopurinol; Febuxostat; Metformin; Xanthine Oxidase Inhibitor; Fluorodeoxyglucose F 18; Glucose; Radiopharmaceutical Agent; Aged; Article; Chronic Kidney Failure; Cohort Analysis; Controlled Study; Estimated Glomerular Filtration Rate; Female; Glucose Transport; Gout; Human; Intra-abdominal Fat; Kidney Function; Major Clinical Study; Male; Nuclear Magnetic Resonance Imaging; Positron Emission Tomography-computed Tomography; Subcutaneous Fat; Complication; Diagnostic Imaging; Disease Exacerbation; Glomerulus Filtration Rate; Metabolism; Middle Aged; Pathophysiology; Aged; Disease Progression; Female; Fluorodeoxyglucose F18; Glomerular Filtration Rate; Glucose; Gout; Humans; Intra-abdominal Fat; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Renal Insufficiency, Chronic; Subcutaneous Fat
- Citation
- Arthritis Care & Research, v.77, no.8, pp 1022 - 1031
- Pages
- 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- Arthritis Care & Research
- Volume
- 77
- Number
- 8
- Start Page
- 1022
- End Page
- 1031
- ISSN
- 2151-464X
2151-4658
- Abstract
- ObjectiveWe evaluate the 18F-fluorodeoxyglucose positron emission tomography (PET) standardized uptake value (SUV) by PET/computed tomography (CT) scans in visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) in patients with and without gout. Additionally, we investigate whether glucose uptake in these tissues predicts the progression of chronic kidney disease (CKD).MethodsWe used International Classification of Diseases, Tenth Revision codes from the University of California San Diego patient database to identify patients with gout and controls, forming a cohort of individuals who underwent PET/CT scans. The mean VAT and SAT maximum SUV (SUVmax) were measured using PET/CT scans and adjusted for potential confounders using inverse probability of weighting analysis. We also employed multivariable linear regression to analyze changes in estimated glomerular filtration rate (eGFR) after PET/CT scans.ResultsThe study included 221 patients, with 120 diagnosed with gout. After the inverse probability of weighting adjustment, the mean VAT and SAT SUVmax were higher in patients with gout (mean VAT SUVmax: beta = 0.09, 95% confidence interval [CI] 0.04-0.15; mean SAT SUVmax: beta = 0.06, 95% CI 0.01-0.12). Additionally, in patients with gout with CKD stage >= 3, higher mean VAT and SAT SUVmax were associated with decreased eGFR in the 5 years following PET/CT scans (mean VAT SUVmax: beta = -1.76, 95% CI -3.50 to -0.01; mean SAT SUVmax: beta = -2.97, 95% CI -5.61 to -0.32).ConclusionElevated glucose uptake-associated metabolic activity in both VAT and SAT was observed in patients with gout, which may contribute to CKD progression among patients with both gout and CKD. imageConclusionElevated glucose uptake-associated metabolic activity in both VAT and SAT was observed in patients with gout, which may contribute to CKD progression among patients with both gout and CKD. image
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Related Researcher
- Lee, Kwang Hoon
- Graduate School (Department of Medicine)