Corrigendum to “Three months extended-release microspheres prepared by multi-microchannel microfluidics in beagle dog models” [Int. J. Pharm. 608 (2021) 121039]

Abstract

The authors regret that the following text must be corrected since Fig. 3c, 3d, 4, 5d, and 5e were processed from the same raw data for one-month dog PK study published in the earlier article (https://doi.org/10.1016/j.ijpharm.2021.120527). The authors would like to apologise for any inconvenience caused. The corrected legends for Figs. 3, 4, and 5 are as below with the reference: Fig. 3. (a) Plasma drug concentration–time profiles after the administration of microspheres based on the ratio of 7502A:API (4:1) and 5002A:API (4:1), (b) cumulative plasma drug concentration–time profiles based on the ratio of 7502A:API (4:1) and 5002A:API (4:1), (c) plasma drug concentration–time profiles based on the ratio of 7502A:API (4:1), 7502A:API (2:1), and 7502A:API (2:1) with 20 mg API (71.4% of dose) (black line), and (d) cumulative plasma drug concentration–time profiles based on the ratio of 7502A:API (4:1), 7502A:API (2:1), and 7502A:API (2:1) with 20 mg API (71.4% of dose) (black line). Each point represents the mean ± SD (n = 9). Red and blue lines in (c) and (d) were generated using the same raw data reported earlier (Kang et al., 2021). Fig. 4. (a) Plasma drug concentration–time profiles after the administration of microspheres based on 2.8 mg drug (10% of dose), 5.6 mg drug (20% of dose), 11.2 mg drug (40% of dose), 16.8 mg drug (60% of dose), and 28 mg drug (100% of dose), and (b) cumulative plasma drug concentration–time profiles after the administration of the microspheres. Each point represents the mean ± SD (n = 5). Results were generated using the same raw data reported earlier (Kang et al., 2021). Fig. 5. (d) Plasma concentration of 1 mg Propecia® tablet, and (e) 1 month simulation study of the plasma concentration of the drug-loaded microspheres injectable. Each point represents the mean ± SD (n = 5). (d) and (e) were generated using the same raw data reported earlier (Kang et al., 2021). © 2021 Elsevier B.V.