Two dimensional FeVO4 nanoflakes decorated on Ti3C2 MXene hybrid nanocomposites as a novel effective electrochemical biosensor for ultrasensitive and selective detection of serotonin (5-HT)

Abstract

Serotonin (5-HT) is a neurotransmitter involved in various pathological and physiological processes. The development of novel electrochemical sensor is of significant interest for effective measurement of 5-HT in pharmaceutical and disease diagnosis applications. In this work, two-dimensional iron vanadate nanoflakes (FeVO4 NFs) supported on Ti3C2 MXene hybrid nanocomposites was fabricated for the ultrasensitive and highly selective electrochemical detection of (5-HT). The morphology and crystalline phase of the as-synthesized nanocomposites was analyzed by various characterization techniques. The morphological studies of the hybrid nanocomposites reveals that FeVO4 NFs are uniformly decorated on the Ti3C2 MXene surface. Differential pulse voltammetry (DPV) and cyclic voltammetry (CV) characterization of FeVO4@Ti3C2 MXene on screen printed carbon electrode (SPCE) exhibits enhanced electrochemical activity towards 5-HT oxidation. Under optimized conditions, FeVO4@Ti3C2 MXene (SPCE) reveals a linear concentration of 25 to 750 nM, with a detection limit of 5.88 nM towards the determination of (5-HT) and the calculated sensitivity of 3.0 mu A mu M- 1 cm- 2. In addition, the fabricated electrochemical biosensor delivers excellent stability, selectivity and reproducibility with the existence of interfering active compounds enabling the detection of 5-HT. Furthermore, the FeVO4@ Ti3C2 MXene (SPCE) biosensor displays satisfactory results in real sample analysis such as human serum.