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Salicinoyl Quinic Acids and Their Prostaglandin E-2 Production Inhibitory Activities from the Fruits of Casearia grewiifolia
- Authors
- Nhoek, Piseth; Ahn, Sungjin; Park, In Guk; Pel, Pisey; Huh, Jungmoo; Kim, Hyun Woo; Ahn, Jongmin; Khiev, Piseth; Choi, Young Hee; Lee, Kyeong; Noh, Minsoo; Chin, Young-Won
- Issue Date
- 24-Sep-2021
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.84, no.9, pp 2437 - 2446
- Pages
- 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 84
- Number
- 9
- Start Page
- 2437
- End Page
- 2446
- ISSN
- 0163-3864
1520-6025
- Abstract
- Phytochemical investigation on the dried fruits of Casearia grewiifolia led to the identification of 10 new salicinoyl quinic acid derivatives (1-10), a new benzoyl quinic acid (11), and two known compounds (12 and 13). The structures of the new compounds were elucidated by interpreting 1D and 2D NMR spectroscopic data including HMBC and EXSIDE along with a chemical method for sugar unit analysis. All isolates were evaluated for their inhibitory activities against prostaglandin E-2 (PGE(2)) production in ultraviolet B (UVB)-irradiated HaCat keratinocytes. Of the isolates tested, compounds 6 and 12 were found to inhibit PGE(2) production with IC50 values of 20.5 and 28.8 mu M, respectively.
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Related Researcher
- Lee, Kyeong
- College of Pharmacy (Department of Pharmacy)