Green-emitting lanthanum niobate mesoporous nanospheroids for near-infrared light responsive cancer theranostics

Abstract

Biomedical applications require nonlinear optical materials with high performance and specific morphology. Among these materials, rare-earth niobates are very promising candidates. However, synthesizing pure-phase rare-earth niobates with controlled shape is challenging. To overcome this obstacle, we present a feasible technique to prepare biocompatible LaNbO4:Er3+/Yb3+ mesoporous nanospheroids with strong upconversion luminescence. We use a pre-Ouzo effect assisted hydrothermal process to obtain the monoclinic phase nanospheroids, which exhibit two-photon excitation induced green emission under 980 nm laser irradiation. We also investigate the energy transfer mechanism between Yb3+ and Er3+ in the LaNbO4 matrix and also explored their pathways in energy level diagram. The cytocompatibility of the LaNbO4:Er3+/Yb3+ mesoporous nanospheroids is verified by Cell Counting Kit-8 assay. Moreover, the cytoplasm and nucleoplasm of LaNbO4:Er3+/Yb3+ mesoporous nanospheroids stained MDA-MB-231 breast cancer cells exhibit upconversion luminescence, indicating that the mesoporous nanospheroids can enter them effectively. Additionally, these nanospheroids have a good ability to deliver DOX to the cancer cells. These results suggest that the LaNbO4:Er3+/Yb3+ mesoporous nanospheroids are promising candidates for luminescence imaging-based cancer diagnosis and therapy. © 2024 Elsevier Ltd and Techna Group S.r.l.