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Cited 2 time in webofscience Cited 3 time in scopus
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Identification of target clusters by using the restricted normal mixture model

Authors
Kim, Seung-GuPark, Jeong-SooLee, Yung-Seop
Issue Date
1-May-2013
Publisher
TAYLOR & FRANCIS LTD
Keywords
EM algorithm; maximum-likelihood method; mean restrictions; microarray gene expression data; restricted normal mixture model; target clustering
Citation
JOURNAL OF APPLIED STATISTICS, v.40, no.5, pp 941 - 960
Pages
20
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF APPLIED STATISTICS
Volume
40
Number
5
Start Page
941
End Page
960
URI
https://scholarworks.dongguk.edu/handle/sw.dongguk/23703
DOI
10.1080/02664763.2012.759192
ISSN
0266-4763
1360-0532
Abstract
This paper addresses the problem of identifying groups that satisfy the specific conditions for the means of feature variables. In this study, we refer to the identified groups as target clusters (TCs). To identify TCs, we propose a method based on the normal mixture model (NMM) restricted by a linear combination of means. We provide an expectationmaximization (EM) algorithm to fit the restricted NMM by using the maximum-likelihood method. The convergence property of the EM algorithm and a reasonable set of initial estimates are presented. We demonstrate the method's usefulness and validity through a simulation study and two well-known data sets. The proposed method provides several types of useful clusters, which would be difficult to achieve with conventional clustering or exploratory data analysis methods based on the ordinary NMM. A simple comparison with another target clustering approach shows that the proposed method is promising in the identification.
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