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A Novel Chemical Compound for Inhibition of SARS Coronavirus Helicaseopen access
- Issue Date
- Nov-2017
- Publisher
- KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
- Keywords
- SARS; helicase; ATP hydrolysis; dsDNA unwinding; cytotoxicity
- Citation
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.27, no.11, pp 2070 - 2073
- Pages
- 4
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
- Volume
- 27
- Number
- 11
- Start Page
- 2070
- End Page
- 2073
- ISSN
- 1017-7825
1738-8872
- Abstract
- We have discovered a novel chemical compound, (E)-3-(furan-2-yl)-N-(4-sulfamoylphenyl) acrylamide, that suppresses the enzymatic activities of SARS coronavirus helicase. To determine the inhibitory effect, ATP hydrolysis and double-stranded DNA unwinding assays were performed in the presence of various concentrations of the compound. Through these assays, we obtained IC50 values of 2.09 +/- 0.30 mu M (ATP hydrolysis) and 13.2 +/- 0.9 mu M (DNA unwinding), respectively. Moreover, we found that the compound did not have any significant cytotoxicity when 40 mu M of it was used. Our results showed that the compound might be useful to be developed as an inhibitor against SARS coronavirus.
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Related Researcher
- Ahn, Hee Chul
- College of Pharmacy (Department of Pharmacy)