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Amine-bearing hydrocarbon cross-links: Tailoring helix stability, hydrophilicity, and synthetic adaptability in peptides
- Authors
- Tran, Duc V.H.; Pham, Thanh K.; Kim, Young-Woo
- Issue Date
- Oct-2024
- Publisher
- Elsevier Ltd.
- Keywords
- Amine cross-link; Peptide drugs; Peptide stapling; Ring-closing metathesis; α-Helix
- Citation
- Bioorganic & Medicinal Chemistry, v.112, pp 1 - 8
- Pages
- 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- Bioorganic & Medicinal Chemistry
- Volume
- 112
- Start Page
- 1
- End Page
- 8
- ISSN
- 0968-0896
1464-3391
- Abstract
- This study comprehensively explored the helix-stabilizing effects of amine-bearing hydrocarbon cross-links (ABXs), revealing their context-dependent nature influenced by various structural parameters. Notably, we identified a 9-atom ABX as a robust helix stabilizer, showcasing versatile synthetic adaptability while preserving peptide water solubility. Future investigations are imperative to fully exploit this system's potential and enrich our chemical toolkit for designing innovative peptide-based biomolecules. © 2024 Elsevier Ltd
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Related Researcher
- Kim, Young Woo
- College of Pharmacy (Department of Pharmacy)