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Amine-bearing hydrocarbon cross-links: Tailoring helix stability, hydrophilicity, and synthetic adaptability in peptides
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tran, Duc V.H. | - |
| dc.contributor.author | Pham, Thanh K. | - |
| dc.contributor.author | Kim, Young-Woo | - |
| dc.date.accessioned | 2024-09-09T07:30:20Z | - |
| dc.date.available | 2024-09-09T07:30:20Z | - |
| dc.date.issued | 2024-10 | - |
| dc.identifier.issn | 0968-0896 | - |
| dc.identifier.issn | 1464-3391 | - |
| dc.identifier.uri | https://scholarworks.dongguk.edu/handle/sw.dongguk/23006 | - |
| dc.description.abstract | This study comprehensively explored the helix-stabilizing effects of amine-bearing hydrocarbon cross-links (ABXs), revealing their context-dependent nature influenced by various structural parameters. Notably, we identified a 9-atom ABX as a robust helix stabilizer, showcasing versatile synthetic adaptability while preserving peptide water solubility. Future investigations are imperative to fully exploit this system's potential and enrich our chemical toolkit for designing innovative peptide-based biomolecules. © 2024 Elsevier Ltd | - |
| dc.format.extent | 8 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | Elsevier Ltd. | - |
| dc.title | Amine-bearing hydrocarbon cross-links: Tailoring helix stability, hydrophilicity, and synthetic adaptability in peptides | - |
| dc.type | Article | - |
| dc.publisher.location | 네델란드 | - |
| dc.identifier.doi | 10.1016/j.bmc.2024.117893 | - |
| dc.identifier.scopusid | 2-s2.0-85202078298 | - |
| dc.identifier.wosid | 001306412500001 | - |
| dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry, v.112, pp 1 - 8 | - |
| dc.citation.title | Bioorganic & Medicinal Chemistry | - |
| dc.citation.volume | 112 | - |
| dc.citation.startPage | 1 | - |
| dc.citation.endPage | 8 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordAuthor | Amine cross-link | - |
| dc.subject.keywordAuthor | Peptide drugs | - |
| dc.subject.keywordAuthor | Peptide stapling | - |
| dc.subject.keywordAuthor | Ring-closing metathesis | - |
| dc.subject.keywordAuthor | α-Helix | - |
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Related Researcher
- Kim, Young Woo
- College of Pharmacy (Department of Pharmacy)