Biocidal Properties of Chitosan-Encapsulated Ternary Titanium Dioxide-Nickel Oxide-Copper Oxide Hybrid Nanomaterials Were Prepared via a Facile One-Pot Precipitation Process

Abstract

Chitosan-encapsulated ternary titanium dioxide-nickel oxide-copper oxide (CTNC) hybrid nanomaterials (HNM) were synthesised via a facile one-pot precipitation method. The synthesised chitosan-titanium dioxide-nickel oxide-copper oxide was characterised by XRD, UV, FTIR, DLS, FESEM, EDAX, and PL tested against G- (gram-negative) bacterial strains such as K. pneumonia, S. dysenteriae, E. coli, P. vulgaris, P. aeruginosa, and V. cholerae, employed by the well method. The CTNC hybrid nanomaterials exhibit a more substantial antibacterial effect against gram-negative bacteria. The MDA-MB-231 cell-line with an IC50 concentration value of 9.8 g/mL was chosen to test CTNC hybrid nanomaterials' anticancer properties against human breast cancer cell lines. The toxicity studies of fibroblast L929 cells showed that the CTNC hybrid nanomaterials were less harmful to healthy cells. As a result, the CTNC hybrid nanomaterials can be used for biomedical and industrial applications to improve human health conditions.