Physicochemical Properties of the Poorly Soluble Isoflavone Class-loaded Hydrocolloid Patch

Abstract

Genistein and daidzein, phytoestrogens belonging to the isoflavone class, have a role in the treatment and prevention of various cancers, antioxidant and anti-inflammation activity. However, it is difficult to deliver through the skin from applying the emulsion such as cream containing them because these drugs are nearly insoluble in aqueous solutions. In this study, the hydrocolloid patch including poorly soluble drugs such as genistein and daidzein was used as the trans dermal drug delivery system (TDDS) to deliver them through the skin. It was confirmed that the patches are helpful for the drugs to be absorb much and more deeply than the cream due to the occlusive effect of patch, which was verified from the porcine skin and the confocal microscopy. The hydrocolloid patch is a better way to deliver the poorly soluble drugs through the skin than the general cosmetics such as emulsion-based cream, and is valuable as effective cosmetics due to its convenient usage.