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A Role of Zinc-Finger Protein 143 for Cancer Cell Migration and Invasion Through ZEB1 and E-Cadherin in Colon Cancer Cells
- Authors
- Paek, A. Rome; Lee, Chang-Hoon; You, Hye Jin
- Issue Date
- Feb-2014
- Publisher
- WILEY-BLACKWELL
- Keywords
- ZNF143; migration; invasion; ZEB1; E-cadherin
- Citation
- MOLECULAR CARCINOGENESIS, v.53, no.S1, pp E161 - E168
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- MOLECULAR CARCINOGENESIS
- Volume
- 53
- Number
- S1
- Start Page
- E161
- End Page
- E168
- ISSN
- 0899-1987
1098-2744
- Abstract
- To investigate the role of zinc-finger protein 143 in cancer cells, we stably introduced ZNF143 expression knockdown by infecting colon cancer cells with short hairpin (sh) RNA-lentiviral particles against ZNF143 (HCT116 sh-ZNF143). Compared to sh-control cells, HCT116 sh-ZNF143 cells showed faster wound healing, increased migration through Transwell chambers, and increased invasion through Matrigel in Transwell chambers. ZNF143 knockdown increased transcriptional expression of ZEB1. Additionally, ZNF143 regulated E-cadherin transcriptional expression. Small interfering-RNA-mediated silencing of ZEB1 expression affected motility in HCT116 sh-ZNF143 cells. These data suggest that ZNF143 is involved in cellular motility through a ZEB1-E-cadherin-linked pathway in colon cancer cells. (c) 2013 Wiley Periodicals, Inc.
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Related Researcher
- Lee, Chang Hoon
- College of Pharmacy (Department of Pharmacy)