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Synthesis and pharmacological evaluation of novel thienopyrimidine and triazolothienopyrimidine derivatives
- Authors
- Mulla, Jameel Ahmed S.; Khazi, Mohammed Iqbal A.; Panchamukhi, Shridhar I.; Gong, Young-Dae; Khazi, Imtiyaz Ahmed M.
- Issue Date
- Jun-2014
- Publisher
- SPRINGER BIRKHAUSER
- Keywords
- Thienopyrimidine; Triazolothienopyrimidine; Gewald reaction; Analgesic; Anti-inflammatory; Antibacterial activity
- Citation
- MEDICINAL CHEMISTRY RESEARCH, v.23, no.6, pp 3235 - 3243
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- MEDICINAL CHEMISTRY RESEARCH
- Volume
- 23
- Number
- 6
- Start Page
- 3235
- End Page
- 3243
- ISSN
- 1054-2523
1554-8120
- Abstract
- Novel tricyclic thienopyrimidines (2, 3, 5, 8) and triazole-fused tetracyclic thienopyrimidines (6a-c and 9a-c) were synthesized from the precursor 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile (1). The structures of newly synthesized compounds were established by spectral and analytical data. The title compounds were screened for analgesic, anti-inflammatory, ulcerogenicity index, and antibacterial activities. Test compounds exhibited significant activity, the compounds (6a-c) and (9a-c) showed more potent analgesic activity, and the compounds (6c) and (9c) showed more potent anti-inflammatory activity than the reference standard Diclofenac Sodium. All the synthesized compounds exhibited remarkable antibacterial activity.
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