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Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPAR alpha/gamma Dual Modulators
- Han, Yujia;
- Liu, Jingjing;
- Ahn, Sungjin;
- An, Seungchan;
- Ko, Hyejin;
- ... Choi, Won Jun;
- 외 7명
WEB OF SCIENCE
13SCOPUS
15초록
Adiponectin secretion-promoting compounds have therapeutic potentials in human metabolic diseases. Diallyl biphenyl-type neolignan compounds, magnolol, honokiol, and 4-O-methylhonokiol, from a Magnolia officinalis extract were screened as adiponectin-secretion promoting compounds in the adipogenic differentiation model of human bone marrow mesenchymal stem cells (hBM-MSCs). In a target identification study, magnolol, honokiol, and 4-O-methylhonokiol were elucidated as PPAR alpha and PPAR gamma dual modulators. Diallyl biphenyl-type neolignans affected the transcription of lipid metabolism-associated genes in a different way compared to those of specific PPAR ligands. The diallyl biphenyl-type neolignan structure provides a novel pharmacophore of PPAR alpha/gamma dual modulators, which may have unique therapeutic potentials in diverse metabolic diseases.
키워드
- 제목
- Diallyl Biphenyl-Type Neolignans Have a Pharmacophore of PPAR alpha/gamma Dual Modulators
- 저자
- Han, Yujia; Liu, Jingjing; Ahn, Sungjin; An, Seungchan; Ko, Hyejin; Shin, Jeayoung C.; Jin, Sun Hee; Ki, Min Won; Lee, So Hun; Lee, Kang Hyuk; Shin, Song Seok; Choi, Won Jun; Noh, Minsoo
- 발행일
- 2020-09
- 유형
- Article
- 권
- 28
- 호
- 5
- 페이지
- 397 ~ 404