상세 보기
- Nhoek, Piseth;
- An, Chae-Yeong;
- Son, Min-Gyung;
- Chae, Hee-Sung;
- Pel, Pisey;
- ... Choi, Won Jun;
- ... Choi, Young Hee;
- 외 3명
WEB OF SCIENCE
5SCOPUS
6초록
More than 20 natural products have been reported to modulate PCSK9-mediated cholesterol regulation, and small-molecule-derived proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors continue to be developed and identified. Here, twelve undescribed clerodane-type diterpenes (1–9 and 12–14) and two known compounds were isolated from the chloroform-soluble extract of the dried fruits of Casearia grewiifolia Vent. using a PCSK9 mRNA expression monitoring assay. Among the undescribed compounds, the stereochemistry of two diastereomeric grewiifolins A and B (1 and 2) were extensively elucidated using 2D Nuclear Overhauser Effect Spectroscopy (NOESY) experiments, excitation-sculptured indirect detection experiments (EXSIDE), interproton distance analyses, and computational calculations that included quantum chemical shift calculations combined with DP4+ analysis. All isolates were assessed for their inhibitory activity against PCSK9 and IDOL mRNA expression. Among the compounds tested, compound 3 inhibited PCSK9 and IDOL mRNA expression. © 2023 Elsevier Ltd
키워드
- 제목
- Stereochemical assignment of clerodane-type diterpenes from the fruits of Casearia grewiifolia and their ability to inhibit PCSK9 expression
- 저자
- Nhoek, Piseth; An, Chae-Yeong; Son, Min-Gyung; Chae, Hee-Sung; Pel, Pisey; Kim, Young-Mi; Khiev, Piseth; Choi, Won Jun; Choi, Young Hee; Chin, Young-Won
- 발행일
- 2023-12
- 유형
- Article
- 저널명
- Phytochemistry
- 권
- 216
- 페이지
- 1 ~ 13