Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris

Lee, Shinae; Son, Min-Gyung; Kim, Young-Mi; An, Chae-Yeong; Kim, Hyun Ji; Nhoek, Piseth; Pel, Pisey; Won, Hongic; Lee, Yoonkyung; Yun, Narae; Paik, Jin-Hyub; Bazarragchaa, Badamtsetseg; Kim, Hyun Woo; Choi, Young Hee; Oh, Won Keun; Lee, Chang Hoon; Chin, Young-Won

doi:10.1016/j.phytochem.2024.114107

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Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris

Lee, Shinae;
Son, Min-Gyung;
Kim, Young-Mi;
An, Chae-Yeong;
Kim, Hyun Ji;
... Kim, Hyun Woo;
... Choi, Young Hee;
... Lee, Chang Hoon;
외 9명

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초록

The isolation of previously undescribed 12 compounds from the MeOH extract of Jacobaea vulgaris whole plants is disclosed, comprising 11 dihydrostilbenes (1–11) and one flavanone (12), and eight known compounds (six flavonoids, one dihydrostilbene, and one caffeoylquinic acid). Structural elucidation employed spectroscopic methods, including 1D and 2D NMR spectroscopy, HRESIMS, and ECD calculations. Evaluation of the compounds’ effects on PCSK9 and LDLR mRNA expression revealed that compounds 1 and 3 downregulated PCSK9 mRNA while increasing LDLR mRNA expression, suggesting potential cholesterol-lowering properties. © 2024 Elsevier Ltd

키워드

Asteraceae; Dihydrostilbenes; Flavonoids; Jacobaea vulgaris; LDLR; PCSK9; RAGWORT SENECIO-JACOBAEA; PYRROLIZIDINE ALKALOIDS; LDL RECEPTOR; PCSK9 INHIBITORS; AERIAL PARTS; 8-PRENYLNARINGENIN; DIVERSITY; IDOL

제목: Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris

저자: Lee, Shinae; Son, Min-Gyung; Kim, Young-Mi; An, Chae-Yeong; Kim, Hyun Ji; Nhoek, Piseth; Pel, Pisey; Won, Hongic; Lee, Yoonkyung; Yun, Narae; Paik, Jin-Hyub; Bazarragchaa, Badamtsetseg; Kim, Hyun Woo; Choi, Young Hee; Oh, Won Keun; Lee, Chang Hoon; Chin, Young-Won

DOI: 10.1016/j.phytochem.2024.114107

발행일: 2024-06

유형: Article

저널명: Phytochemistry

권: 222

페이지: 1 ~ 11