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Palladium-Catalyzed Synthesis of Pyrrolo[1,2-α]Pyrazines From N-Phenacyl Pyrrole-2-Carbonitriles and Aryl Boronic Acids
- Park, Hyejun;
- Shim, Seunghwan;
- Jeon, Hayoung;
- Lee, Hwayoung;
- Lee, Kiho;
- ... Lee, Kyeong;
- 외 3명
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1초록
Herein, we have developed palladium-trifluoroacetate-catalyzed carbo-palladation reaction of pyrrole-2-carbonitriles and aryl boronic acids leading to functionally diverse pyrrolo[1,2-alpha]pyrazines under thoroughly optimized reaction conditions. The reaction proceeded smoothly and allowed the diversity-oriented synthesis of pyrrolo[1,2-alpha]pyrazines with broad substrate scope with respect to pyrrole-2-carbonitriles and aryl boronic acids.
키워드
aryl boronic acids; carbo-palladation; N-phenacyl pyrrole-2-carbonitriles; pd(TFA)(2); pyrrolo[1,2-alpha]pyrazines; ONE-POT SYNTHESIS; CASCADE REACTIONS; CONCISE; ACCESS; CARBOPALLADATION; CONSTRUCTION; HETEROCYCLES; PYRROLE
- 제목
- Palladium-Catalyzed Synthesis of Pyrrolo[1,2-α]Pyrazines From N-Phenacyl Pyrrole-2-Carbonitriles and Aryl Boronic Acids
- 저자
- Park, Hyejun; Shim, Seunghwan; Jeon, Hayoung; Lee, Hwayoung; Lee, Kiho; Lee, Kyeong; Lee, Jae Kyun; Jalani, Hitesh B.; Choi, Yongseok
- 발행일
- 2024-11
- 유형
- Article
- 권
- 61
- 호
- 11
- 페이지
- 1 ~ 9