A Role of Zinc-Finger Protein 143 for Cancer Cell Migration and Invasion Through ZEB1 and E-Cadherin in Colon Cancer Cells

Paek, A. Rome; Lee, Chang-Hoon; You, Hye Jin

doi:10.1002/mc.22083

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A Role of Zinc-Finger Protein 143 for Cancer Cell Migration and Invasion Through ZEB1 and E-Cadherin in Colon Cancer Cells

Paek, A. Rome;
Lee, Chang-Hoon;
You, Hye Jin

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35

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36

초록

To investigate the role of zinc-finger protein 143 in cancer cells, we stably introduced ZNF143 expression knockdown by infecting colon cancer cells with short hairpin (sh) RNA-lentiviral particles against ZNF143 (HCT116 sh-ZNF143). Compared to sh-control cells, HCT116 sh-ZNF143 cells showed faster wound healing, increased migration through Transwell chambers, and increased invasion through Matrigel in Transwell chambers. ZNF143 knockdown increased transcriptional expression of ZEB1. Additionally, ZNF143 regulated E-cadherin transcriptional expression. Small interfering-RNA-mediated silencing of ZEB1 expression affected motility in HCT116 sh-ZNF143 cells. These data suggest that ZNF143 is involved in cellular motility through a ZEB1-E-cadherin-linked pathway in colon cancer cells. (c) 2013 Wiley Periodicals, Inc.

키워드

ZNF143; migration; invasion; ZEB1; E-cadherin; EPITHELIAL-MESENCHYMAL TRANSITIONS; GROWTH-FACTOR RECEPTOR; TUMOR PROGRESSION; BREAST-CANCER; TRANSCRIPTIONAL REGULATION; ADHESION MOLECULES; PROSTATE-CANCER; GENE-EXPRESSION; TARGETING ZEB1; UP-REGULATION

제목: A Role of Zinc-Finger Protein 143 for Cancer Cell Migration and Invasion Through ZEB1 and E-Cadherin in Colon Cancer Cells

저자: Paek, A. Rome; Lee, Chang-Hoon; You, Hye Jin

DOI: 10.1002/mc.22083

발행일: 2014-02

유형: Article

저널명: Molecular Carcinogenesis

권: 53

호: S1

페이지: E161 ~ E168