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Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II
- Yang, Jee Sun;
- Song, Doona;
- Ko, Won Jin;
- Kim, Bunyea;
- Kim, Bo-Kyung;
- ... Lee, Kyeong;
- 외 5명
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16초록
A series of novel aliphatic amido-quaternary ammonium salts were synthesized and evaluated for their anticancer effects involving induction of RhoB. Most of these compounds, featuring open-ring forms of aliphatic amido-quaternary ammonium salts, exhibited potent anti-proliferative activities in human cancer cell lines, including PC-3, NUGC-3, MDA-MB-231, ACHN, HCT-15, and NCI-H23. In further evaluation, the representative compound N,N-diethyl-N-(2-(N-methyltetradecanamido)ethyl)prop-2-en-1-aminium bromide (3b) exhibited potent pro-apoptotic activity, through RhoB activation, in HeLa cells. (C) 2013 Elsevier Masson SAS. All rights reserved.
키워드
Aliphatic amido-quaternary ammonium salts; Open-ring form of aliphatic amido-quaternary ammonium salts; RhoB; GTPase RAt Sarcoma (Ras); Perifosine; NSC126188; RHOB EXPRESSION; RAS TRANSFORMATION; PROTEIN-KINASES; HUMAN CANCER; APOPTOSIS; CELLS; INHIBITORS
- 제목
- Synthesis and biological evaluation of novel aliphatic amido-quaternary ammonium salts for anticancer chemotherapy: Part II
- 저자
- Yang, Jee Sun; Song, Doona; Ko, Won Jin; Kim, Bunyea; Kim, Bo-Kyung; Park, Song-Kyu; Won, Misun; Lee, Kiho; Lee, Kyeong; Kim, Hwan Mook; Han, Gyoonhee
- 발행일
- 2013-05
- 유형
- Article
- 권
- 63
- 페이지
- 621 ~ 628