Identification of target clusters by using the restricted normal mixture model

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초록

This paper addresses the problem of identifying groups that satisfy the specific conditions for the means of feature variables. In this study, we refer to the identified groups as target clusters (TCs). To identify TCs, we propose a method based on the normal mixture model (NMM) restricted by a linear combination of means. We provide an expectationmaximization (EM) algorithm to fit the restricted NMM by using the maximum-likelihood method. The convergence property of the EM algorithm and a reasonable set of initial estimates are presented. We demonstrate the method's usefulness and validity through a simulation study and two well-known data sets. The proposed method provides several types of useful clusters, which would be difficult to achieve with conventional clustering or exploratory data analysis methods based on the ordinary NMM. A simple comparison with another target clustering approach shows that the proposed method is promising in the identification.

키워드

EM algorithmmaximum-likelihood methodmean restrictionsmicroarray gene expression datarestricted normal mixture modeltarget clusteringDIFFERENTIAL GENE-EXPRESSIONVARIABLE SELECTIONREGULARIZATION
제목
Identification of target clusters by using the restricted normal mixture model
저자
Kim, Seung-GuPark, Jeong-SooLee, Yung-Seop
DOI
10.1080/02664763.2012.759192
발행일
2013-05-01
유형
Article
저널명
Journal of Applied Statistics
40
5
페이지
941 ~ 960