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초록
1. Novel cudraisoflavone J analogs were designed and synthesized. 2. Compounds 13m and 24 extensively inhibited 6-OHDA- and rotenone-induced cell death. 3, 13m and 24 increased expression levels of HO-1 and Nrf2. 4. Nrf2/HO-1 pathway is mediated by phosphorylated ERK1/2, JNK, and Akt in PC12 cells. 5. 13m and 24 may be promising therapeutic candidates to prevent and/or treat PD.
- 제목
- [우선권]신규 쿠드라플라본 J 유도체 (가칭)
- 제목 (타언어)
- Novel cudraisoflavone J derivatives as potent neuroprotective agents for the treatment of Parkinson’s disease via the activation of Nrf2/HO-1 signaling
- 저자
- 이경; 조정숙; 이창훈
- 발행일
- 2025-04-21
- 출원번호
- 10-2023-0028860
- 등록번호
- 10-2800007
- 출원일
- 2023-03-06
- 등록일
- 2025-04-21