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Schweinfurthins A-Q: isolation, synthesis, and biochemical properties
- Harmalkar, Dipesh S.;
- Mali, Jyotirling R.;
- Sivaraman, Aneesh;
- Choi, Yongseok;
- Lee, Kyeong
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WEB OF SCIENCE
18Citations
SCOPUS
22초록
Stilbene analogues have shown remarkable structural diversity constituting simple or tangled structures, which have attracted the synthetic as well as the medicinal chemistry communities. Schweinfurthins are a family of prenylated/geranylated/farnesylated stilbenes that are isolated from an African plant belonging to the Macaranga species. These compounds have displayed potency towards central nervous system, renal and breast cancer cell lines. Specifically, these compounds have been found to be potent and selective inhibitors of cell growth in the National Cancer Institute's 60 cell-line screen. In this review article, we described the isolation, synthesis, and biochemical properties of schweinfurthins.
키워드
MACARANGA-SCHWEINFURTHII; ANTIOXIDANT ACTIVITY; DRUG DISCOVERY; ASYMMETRIC EPOXIDATION; ARUNDINA-GRAMINIFOLIA; PRENYLATED STILBENES; OLEFIN CYCLIZATION; GERANYL STILBENES; NATURAL-PRODUCTS; BREAST-CANCER
- 제목
- Schweinfurthins A-Q: isolation, synthesis, and biochemical properties
- 저자
- Harmalkar, Dipesh S.; Mali, Jyotirling R.; Sivaraman, Aneesh; Choi, Yongseok; Lee, Kyeong
- 발행일
- 2018
- 유형
- Review
- 저널명
- RSC Advances
- 권
- 8
- 호
- 38
- 페이지
- 21191 ~ 21209