ScholarWorks@동국대학교

초록

Wireless ultrasonic power transfer for implantable medical devices has garnered significant interest, particularly for deeply implanted systems that require reliable energy delivery. This led to the discovery of a nascent discipline, Acousto-Bioelectronics, which studies the transduction of acoustic energy within the human body. In this work, we elucidated the untapped potential of the coupling effect of piezoelectricity and flexoelectricity via a miniaturized pentagonal pyramid-shaped barium titanate ultrasonic receiver for implantable medical devices. Providing reliable power, a highly integrated Acousto-Bioelectronics system augments the controlled generation of light, oxygen, and electric fields for potent multimodal cancer therapy. Combining twelve pyramid receivers forms a dodecahedron, establishing a wireless omnidirectional powering microsystem platform. Optimization through finite element analysis and experimental validation demonstrates that a single unit cell (volume of 18.11 mm³) generates an output power of 2.39 mW (optimized impedance of 400 Ω). This power is sufficient to simultaneously generate light (I = 10.1 mW/cm²), oxygen (4.301 µmol/L/min), and an electric field (up to 3 V/cm), highlighting its potential for localized regional targeted therapy of solid tumors. © 2025 Elsevier Ltd

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