상세 보기
- Kim, Dae Gyu;
- Kim, Minkyoung;
- Goo, Ja-il;
- Kong, Jiwon;
- Harmalkar, Dipesh S.;
- ... Choi, Won Jun;
- ... Lee, Chang Hoon;
- ... Lee, Kyeong;
- 외 13명
WEB OF SCIENCE
2SCOPUS
2초록
AIMP2-DX2 (hereafter DX2) is an oncogenic variant of aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) that mediates tumorigenic interactions with various factors involved in cancer. Reducing the levels of DX2 can effectively inhibit tumorigenesis. We previously reported that DX2 can be degraded through Siah1-mediated ubiquitination. In this study, we identified a compound, SDL01, which enhanced the interaction between DX2 and Siah1, thereby facilitating the ubiquitin-dependent degradation of DX2. SDL01 was found to bind to the pocket surrounding the N-terminal flexible region and GST domain of DX2, causing a conformational change that stabilized its interaction with Siah1. Our findings demonstrate that protein-protein interactions (PPIs) can be modulated through chemically induced conformational changes. © 2024 Elsevier Ltd
키워드
- 제목
- Chemical induction of the interaction between AIMP2-DX2 and Siah1 to enhance ubiquitination
- 저자
- Kim, Dae Gyu; Kim, Minkyoung; Goo, Ja-il; Kong, Jiwon; Harmalkar, Dipesh S.; Lu, Qili; Sivaraman, Aneesh; Nada, Hossam; Godesi, Sreenivasulu; Lee, Hwayoung; Song, Mo Eun; Song, Eunjoo; Han, Kang-Hyun; Kim, Woojin; Kim, Pilhan; Choi, Won Jun; Lee, Chang Hoon; Lee, Sunkyung; Choi, Yongseok; Kim, Sunghoon; Lee, Kyeong
- 발행일
- 2024-11
- 유형
- Article
- 권
- 31
- 호
- 11
- 페이지
- 1958 ~ 1968.e8