Structures and Biosynthetic Pathway of Pulvomycins B-D: 22-Membered Macrolides from an Estuarine Streptomyces sp.

Moon, Kyuho; Cui, Jinsheng; Kim, Eunji; Riandi, Evan Setiawan; Park, So Hyun; Byun, Woong Sub; Kal, Youngju; Park, Jun Young; Hwang, Sunghoon; Shin, Daniel; Sun, Jeongyoon; Oh, Ki-Bong; Cha, Sangwon; Shin, Jongheon; Lee, Sang Kook; Yoon, Yeo Joon; Oh, Dong-Chan

doi:10.1021/acs.orglett.0c01249

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Structures and Biosynthetic Pathway of Pulvomycins B-D: 22-Membered Macrolides from an Estuarine Streptomyces sp.

Moon, Kyuho;
Cui, Jinsheng;
Kim, Eunji;
Riandi, Evan Setiawan;
Park, So Hyun;
... Cha, Sangwon;
외 11명

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26

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28

초록

Pulvomycins B-D (1-3) were discovered from an estuarine Streptomyces strain along with the known pulvomycin (4). The 22-membered macrocyclic lactone structures of 1-3 were determined based on the interpretation of NMR, UV, and MS data, the modified Mosher's method, and Kishi's bidentate chiral solvent NMR spectroscopy. Genomic analysis of the bacterial strain revealed the biosynthetic gene cluster of pulvomycin and enabled us to propose the trans-acyltransferase polyketide biosynthetic pathway. Pulvomycin D displayed potent cytotoxic activity against various cancer cell lines.

키워드

POLYKETIDE; CONFIGURATION; LABILOMYCIN

제목: Structures and Biosynthetic Pathway of Pulvomycins B-D: 22-Membered Macrolides from an Estuarine Streptomyces sp.

저자: Moon, Kyuho; Cui, Jinsheng; Kim, Eunji; Riandi, Evan Setiawan; Park, So Hyun; Byun, Woong Sub; Kal, Youngju; Park, Jun Young; Hwang, Sunghoon; Shin, Daniel; Sun, Jeongyoon; Oh, Ki-Bong; Cha, Sangwon; Shin, Jongheon; Lee, Sang Kook; Yoon, Yeo Joon; Oh, Dong-Chan

DOI: 10.1021/acs.orglett.0c01249

발행일: 2020-07-17

유형: Article

저널명: Organic Letters

권: 22

호: 14

페이지: 5358 ~ 5362