Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

Yoo, Hunseung; Chae, Hee-Sung; Kim, Young-Mi; Kang, Minseok; Ryu, Keun Ho; Ahn, Hee Chul; Yoon, Kee Dong; Chin, Young-Won; Kim, Jinwoong

doi:10.1016/j.bmcl.2014.10.077

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Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

Yoo, Hunseung;
Chae, Hee-Sung;
Kim, Young-Mi;
Kang, Minseok;
Ryu, Keun Ho;
... Ahn, Hee Chul;
외 3명

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38

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SCOPUS

40

초록

Three new compounds (1-3) and 20 known compounds were isolated from the rhizomes and roots of Sophora tonkinensis, and all the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells stimulated by PMA plus ionophore, A23187. Of the tested compounds, compounds 1, 5, 9, and 21 were found to potently inhibit IL-6 production with IC50 values of 1.62, 0.73, 3.01, and 4.02 mu M, respectively. (C) 2014 Elsevier Ltd. All rights reserved.

키워드

Sophora tonkinensis; Flavonoid; Arylbenzofruran; Interleukin-6; Anti-allergy; GLYCYRRHIZA-URALENSIS; CONSTITUENTS; ALKALOIDS

제목: Flavonoids and arylbenzofurans from the rhizomes and roots of Sophora tonkinensis with IL-6 production inhibitory activity

저자: Yoo, Hunseung; Chae, Hee-Sung; Kim, Young-Mi; Kang, Minseok; Ryu, Keun Ho; Ahn, Hee Chul; Yoon, Kee Dong; Chin, Young-Won; Kim, Jinwoong

DOI: 10.1016/j.bmcl.2014.10.077

발행일: 2014-12-15

유형: Article

저널명: Bioorganic and Medicinal Chemistry Letters

권: 24

호: 24

페이지: 5644 ~ 5647