Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability

Jang, Hye Min; Jung, Myung Hwan; Lee, Jae Sang; Lee, Jun Sig; Lim, In-Cheol; Im, Hyunsik; Kim, Sang Wook; Kang, Sung-A; Cho, Won-Je; Park, Jun Kue

doi:10.3390/nano12162791

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Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability

Jang, Hye Min;
Jung, Myung Hwan;
Lee, Jae Sang;
Lee, Jun Sig;
Lim, In-Cheol;
외 5명

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초록

We have developed chelator-free copper-64-incorporated iron oxide (IO) nanoparticle (NPs) which have both magnetic and radioactive properties being applied to positron emission tomography (PET)-magnetic resonance imaging (MRI). We have found that the IO nanoparticles composed of radioactive isotope Cu-64 may act as a contrast agent being a diagnostic tool for PET as well as a good T-2 MRI nanoprobe due to their good r(2)/r(1) ratio. Furthermore, we demonstrate that the Cu-64 incorporation at the core of core-shell-structured IO NPs exhibits a good in vivo stability, giving us an insightful strategy for the design of a contrast agent for the PET-MRI system.

키워드

superparamagnetic nanoparticles; magnetic relaxivity; PET-MRI; multimodal imaging; contrast agents; nanoparticles; silica core-shell; MAGNETIC NANOPARTICLES; SIZE

제목: Chelator-Free Copper-64-Incorporated Iron Oxide Nanoparticles for PET/MR Imaging: Improved Radiocopper Stability and Cell Viability

저자: Jang, Hye Min; Jung, Myung Hwan; Lee, Jae Sang; Lee, Jun Sig; Lim, In-Cheol; Im, Hyunsik; Kim, Sang Wook; Kang, Sung-A; Cho, Won-Je; Park, Jun Kue

DOI: 10.3390/nano12162791

발행일: 2022-08

유형: Article

저널명: Nanomaterials

권: 12

호: 16

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