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Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment
- Park, Mi Kyung;
- Lee, Chang Hoon
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11초록
Sphingosylphosphorylcholine (SPC) is a unique type of lysosphingolipid found in some diseases, and has been studied in cardiovascular, neurological, and inflammatory phenomena. In particular, SPC's studies on cancer have been conducted mainly in terms of effects on cancer cells, and relatively little consideration has been given to aspects of tumor microenvironment. This review summarizes the effects of SPC on cancer and tumor microenvironment, and presents the results and prospects of modulators that regulate the various actions of SPC.
키워드
inflammatory; lysosphingolipids; neurological; sphingosylphosphorylcholine; tumor microenvironment; PROTEIN-KINASE-C; KERATIN 8 PHOSPHORYLATION; COUPLED RECEPTORS GPR3; MESENCHYMAL STEM-CELLS; STRESS FIBER FORMATION; LYSOPHOSPHATIDIC ACID; EICOSAPENTAENOIC ACID; CEREBRAL VASOSPASM; TGF-BETA; LYSOPHOSPHOLIPID RECEPTORS
- 제목
- Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment
- 저자
- Park, Mi Kyung; Lee, Chang Hoon
- 발행일
- 2019-11
- 유형
- Review
- 저널명
- Cancers
- 권
- 11
- 호
- 11