@

초록

Backgrounds/Aims: Calcium is a preventive factor for colorectal cancer, which develops fromcolorectal adenoma. This study aimed to investigate the association between dietary calciumintake and prevalence of colorectal adenoma among Korean adults. Methods: Overall, 612 participants aged ≥ 20 years who underwent gastrointestinal endoscopyat 8 medical centers from 2021 to 2023 were included. Dietary calcium intake was assessedusing a food frequency questionnaire and was energy-adjusted using the residual model. Multivariatelogistic regression models were used to calculate for the odds ratios (ORs) and 95%confidence intervals (CIs). The associations between dietary calcium intake and colorectaladenoma prevalence were also assessed according to the anatomic subsites and adenoma status(advanced or nonadvanced). Results: Among the 612 participants, 269 were diagnosed with colorectal adenoma (170 menand 99 women). With respect to the gender-specific association, low dietary calcium intake wasassociated with higher prevalence of colorectal adenoma among men (ORs [95% CIs]: 2.13 [0.50–9.00] for < 250 mg/d; 3.53 [1.06–11.76], 250 to < 350 mg/d; and 1.84 [0.63–5.35], 350 to < 650mg/d, compared to ≥ 650 mg/d of dietary calcium [p for trend = 0.07]). Similar association wasobserved among women, but neither the association nor trend was statistically significant (p fortrend = 0.59). These inverse associations remained similar for distal colon/rectal adenoma amongwomen and advanced adenoma among men. Conclusions: Low dietary calcium intake was associated with high colorectal adenoma prevalence,particularly among men. Given the limited number of studies among Asian populations,our findings should be replicated in other Asian groups.

키워드