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Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes
- Lee, Kyeong;
- Ban, Hyun Seung;
- Naik, Ravi;
- Hong, Ye Seul;
- Son, Seohyun;
- 외 5명
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Tracking the target: To identify a protein that binds directly to the HIF-1α inhibitor LW6, a series of new chemical probes were synthesized with a clickable tag and/or a photoactivatable moiety. LW6 was found to be localized to the mitochondria (see picture) and MDH2 was identified as a target protein of LW6. These results indicate that the HIF-1α inhibitory activity of LW6 is a consequence of MDH2 suppression. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
키워드
click chemistry; fluorescent probes; HIF inhibitors; malate dehydrogenase2; photoaffinity labeling; INDUCIBLE FACTOR-I
- 제목
- Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes
- 저자
- Lee, Kyeong; Ban, Hyun Seung; Naik, Ravi; Hong, Ye Seul; Son, Seohyun; Kim, Bo-Kyung; Xia, Yan; Song, Kyung Bin; Lee, Hong-Sub; Won, Misun
- 발행일
- 2013-09-23
- 유형
- Article
- 권
- 52
- 호
- 39
- 페이지
- 10286 ~ 10289