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Calcium(ii)-catalyzed [2+3] annulation of enynones: a sustainable approach to 9H-pyrrolo[1,2-a]indole frameworks
- Kale, Ashok;
- Rivonker, Shubham C.;
- Kim, Jong-hyuk;
- Hwang, Jong Yeon;
- Choi, Yongseok;
- ... Lee, Kyeong
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1초록
A Ca(ii)-catalyzed, atom-economic, and regioselective [2+3] annulation reaction has been developed to synthesize 9H-pyrrolo[1,2-a]indoles by using easily accessible tryptamines and enynones. This protocol exhibits broad functional group tolerance; thus, 9H-pyrrolo[1,2-a]indole frameworks with diverse substitution patterns can be synthesized. The synthetic utility of this method is further demonstrated through its effectiveness in gram-scale preparations and versatile synthetic transformations.
키워드
Alcohol; Calcium; Calcium Compounds; Polycyclic Aromatic Hydrocarbons; Regioselectivity; Synthesis (chemical); Annulation Reactions; Atom Economic; Functionals; Gram Scale; Regio-selective; Substitution Patterns; Synthesised; Synthetic Transformations; Synthetic Utility; Tryptamines; Catalysis; 9h Pyrrolo[1,2 A]indole; Alcohol; Calcium; Chemical Compound; Enynone; Ketone; Unclassified Drug; Tryptamine Derivative; Antineoplastic Activity; Article; Catalysis; Chemical Analysis; Drug Toxicity; Economic Aspect; Nonhuman; Nuclear Magnetic Resonance; Synthetic Biology; X Ray Crystallography; Annulation Reaction; Article; Controlled Study; Drug Analysis; Drug Development; STABILITY; INDOLES
- 제목
- Calcium(ii)-catalyzed [2+3] annulation of enynones: a sustainable approach to 9H-pyrrolo[1,2-a]indole frameworks
- 저자
- Kale, Ashok; Rivonker, Shubham C.; Kim, Jong-hyuk; Hwang, Jong Yeon; Choi, Yongseok; Lee, Kyeong
- 발행일
- 2025-07
- 유형
- Article
- 권
- 61
- 호
- 62
- 페이지
- 11689 ~ 11692
- 언어
- ENG
- 출판사
- Royal Society of Chemistry
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- E 1364-548X
P 1359-7345