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초록

In order to realize a porous material for a stable reservoir as well as stimulus-responsive release of protein, we designed a metal oxide with a pore dimension matching with protein and with the phase transformation ability under a specific ionic condition. Mixed metal oxide with Mg-Al composition (CMMO) was synthesized to have an ordered hierarchical pore by nanocasting using ordered mesoporous carbon (CMK-3) template. Complete precursor infiltration and confined crystallization within the CMK-3 channels form small oxide crystallites with hierarchical ordering, giving rise to a narrow mesopore distribution (∼4 nm) and a high specific surface area (245 m2/g). Two model proteins, albumin and fibrinogen, with different shapes and sizes, were incorporated into CMMO, taking advantage of the dimensional matching between the hydrodynamic size of the protein and the pore. The CMMO exhibits an extremely high protein adsorption capacity, 706 mg/g and 635 mg/g for albumin and fibrinogen, compared with other porous materials, which is attributed to not only the size matching of the pore but also enhanced surface accessibility. The loaded protein was stably retained under deionized water, while the protein burst out under the stimulation of adding dodecyl sulfate anionic solution, utilizing the memory effect of metal oxide into metal hydroxide. © 2026

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