Factors associated with shock-refractory prehospital cardiac arrest
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초록

A significant number of out-of-hospital cardiac arrest (OHCA) patients experience refractory ventricular arrhythmias despite prompt defibrillation. These refractory arrhythmias are associated with poor clinical outcomes, underscoring the need to investigate improved management strategies. Therefore, this study aimed to identify factors associated with shock-refractory OHCA during the prehospital stages of resuscitation. This multicenter observational study included adult OHCA patients (age ≥ 18 years) from October 2015 to June 2022 who required at least one prehospital defibrillation. This study’s primary endpoint was shock-refractory OHCA, defined as three defibrillation shocks during resuscitation. A logistic regression analysis was performed to identify factors associated with shock-refractory OHCA. Among the 4320 patients included, 1961 (45.4%) experienced shock-refractory OHCA. Male sex (adjusted odds ratio [aOR], 1.423; 95% confidence interval [CI], 1.209–1.676), bystander automated external defibrillator (AED) shock (OR 2.350; 95% CI 1.426–3.968), and initial shockable rhythm (OR 1.739; 95% CI 1.490–2.030) were associated with a high risk of shock-refractory, while old age (OR 0.993; 95% CI 0.989–0.998) and receive bystander cardiopulmonary resuscitation (CPR) (OR 0.829; 95% CI 0.718–0.958) were associated with a low risk of shock-refractory OHCA. This study showed that the prehospital factors of age, sex, initial rhythm, AED shock source, and absence of bystander CPR were associated with shock-refractory OHCA. © 2025 Elsevier B.V., All rights reserved.

키워드

Cardiopulmonary ResuscitationOut-of-hospital Cardiac ArrestPredictive FactorsShock-refractoryShockable RhythmAdultAgedCardioversionClinical TrialDefibrillatorEmergency Health ServiceFemaleHumanMaleMiddle AgedMulticenter StudyOut Of Hospital Cardiac ArrestProceduresResuscitationRisk FactorTherapyAdultAgedCardiopulmonary ResuscitationDefibrillatorsElectric CountershockEmergency Medical ServicesFemaleHumansMaleMiddle AgedOut-of-hospital Cardiac ArrestRisk Factors
제목
Factors associated with shock-refractory prehospital cardiac arrest
저자
Yoo, Kyung HunKo, Byuk SungKim, Won YoungLim, Tae HoKang, HyunggooJaehoon OhJuncheol LeeSang Kuk HanPhil Cho ChoiYoung Hwan LeeSang O. ParkJong Seok LeeKi Young JeongSung Hyuk ChoiYoung Hoon YoonSu Jin KimKap Su HanMin Seob SimGun Tak LeeYoun Jung KimJong Whan ShinHui Jai LeeKeun Hong ParkHahn Bom KimYoo Seok ParkArom ChoiTae Young KongHyuna HwangYoungsuk ChoGu Hyun KangYong Soo JangSung Wook ParkWook Tae YangHyun Wook RyuJae Yun AhnHyuk Jun YangJae-hyug WooSung Hyun YunChong Sun KimSun Pyo KimJin Woong LeeWonjoon JeongSung Soo ParkJae Kwang LeeRyeok AhnWook Jin ChoiBang Shill RheeYou Hwan JoSung Min ParkIn Byung KimKi Ok AhnSe Joong AhnSeung Cheol LeeSang Hun LeeKyeong Min LeeYoung Sik KimJin Sik ParkMyung Hee ParkDai Han WiJin Kun BaeYong Hee LeeSang Ook HaWon Seok YangJu Ok ParkHang A. ParkKyoung Chul ChaWoo Jin JungTaek Geun OhkMyoung Cheol ShinAn Mu EobKyung Sook ParkSang Chul KimGwan Jin ParkHan Joo ChoiYong Oh KimTae Oh JungJae Chol YoonYoung Tae ParkJu Taek LeeJin Hee JeongSang Bong LeeWon KimYi Sang MoonSung Wook SongSeo Young KoJoonmyoung KwonEui Hyuk KangSang Chan JinTae-kwon KimChang Sun KimHyun Goo ShinDong Sun ChoiChul Min HaJai Woog KoYun Jeong HwangSung Phil ChungKyung Jun SongSang Hoon NaGyu Chong ChoSeung Sik HwangSung Oh HwangSang ShinHyuk Jun YangJeong Ho ParkJong Hak ParkJin Hee JungKyoung Chul ChaKim, Ji-hoonChoi, YeonghoChoi, SeulkiLee, Se-jinJoo, Hye Jee
DOI
10.1038/s41598-025-11524-7
발행일
2025-12
유형
Article
저널명
Scientific Reports
15
1