Peptide-nanoparticle conjugates for clustering-driven enhancement of NK cell antitumor activity

  • Lee, Eunmi
  • Kim, Min Gyu
  • Son, ChaeYeon
  • Kim, Joo-young
  • Kim, Kyobum
  • 외 3명
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초록

Ex vivo priming offers an opportunity to enhance NK cell antitumor activity prior to therapeutic application. Herein, NKG2D-targeting peptide-nanoparticle conjugates were developed as a clustering-driven priming platform. Multivalent presentation of NKG2D-binding peptides induced NK cell clustering, enhanced cytokine secretion, and improved cytotoxicity against MDA-MB-231 cells.

키워드

REQUIREMENTLIGANDSNKG2D
제목
Peptide-nanoparticle conjugates for clustering-driven enhancement of NK cell antitumor activity
저자
Lee, EunmiKim, Min GyuSon, ChaeYeonKim, Joo-youngKim, KyobumBu, JiyoonShin, KwangsooJeong, Woo-jin
DOI
10.1039/d6cc03256g
발행일
2026-08
유형
Article; Early Access
저널명
Chemical Communications